SB-431542

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SB-431542

品牌： Absin

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参数

分子式：

C₂₂H₁₆N₄O₃

分子量：

384.39

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产品介绍

产品信息

抗原名称

ALK4；ALK7；ALK5

商品描述

SB-431542 is a potent and selective inhibitor of ALK5 with IC50 of 94 nM, 100-fold more selective for ALK5 than p38 MAPK and other kinases.

分子量

384.39

纯度

>98%

可溶性

DMSO : 38.4 mg/mL(100 mM)
Ethanol : 3.8 mg/mL(10 mM)

外观

黄色至粉色固体

In vitro(体外研究)

SB-431542 inhibits TGF-beta1-induced fibronectin mRNA formation while displaying no measurable cytotoxicity in the 48 h XTT assay. SB-431542 (1 μM) significantly reduced the TGFβ–induced nuclear accumulation of Smad proteins. The IC50 for inhibiting TGFβ–induced nuclear fluorescence is approximately 50 nM. BMP-stimulated Smad1 nuclear fluorescence in MG63 cells was unaffected by SB-431542. the synergistic action of two inhibitors of SMAD signaling, Noggin and SB431542, is sufficient to induce rapid and complete neural conversion of >80% of hES cells under adherent culture conditions.

In vivo(体内研究)

SB-431542 augmented the capacity of bone marrow dendritic cells (BM-DCs) and human DCs to incorporate FITC-conjugated dextran. Intraperitoneal administration of SB-431542 initiated 3 and 7 days after the implantation of colon-26 cancer cells into the peritoneal cavity of BALB/c mice significantly induced CTL activity against colon-26. SB-431542 significantly inhibited lung metastasis from transplanted 4T1 mammary tumors in Balb/c mice.

背景

别名

SB431542；SB 431542

分子式

C₂₂H₁₆N₄O₃

CAS号

301836-41-9

制备和贮存

保存方式

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

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货号：

abs810481-5mg

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