Shc (PG-797)

mouse

Shc抗体(PG-797)是小鼠单克隆IgG1 κ, 在78篇文献中引用，规格为200 µg/mlraised against amino acid residues 476-583 of Shc of human origin抗-Shc 抗体 (PG-797) 推荐用于 WB, IP, IF, IHC(P) 和 FCM，检测mouse, rat 和human 来源的 Shc p66, p52 and p46抗-Shc 抗体 (PG-797) 可偶联 琼脂糖 用于 IP; HRP 用于 WB, IHC(P) 和 ELISA; 还可偶联 藻红蛋白 或者 FITC 用于 IF, IHC(P) 和 FCM还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统关于如何获取Shc (PG-797): sc-967的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。m-IgG1 BP-HRP 是Shc Antibody (PG-797) for WB and IHC(P)首选应用二抗. 这些试剂现在以套装形式提供Shc Antibody (PG-797) (见下方订购信息). 查看产品引用文献(78) Growth factor triggering of protein tyrosine kinase receptors induces signals that cascade to the nucleus activating mitogenic, as well as other, responses. Critical components of this process include adapter proteins such as Shc and IRS-1 that lack detectable catalytic activity. These are immediate substrates of receptor tyrosine kinase activity and serve to physically link activated receptors to downstream signaling components. Whereas Shc has been implicated in signaling by diverse receptor families, IRS-1 serves primarily as the major insulin receptor substrate. Shc also participates in insulin signaling by linking the insulin receptor to Ras by forming complexes with the adapter protein GRB2 and Sos independently of IRS-1. A protein immunologically related to IRS-1, originally designated 4PS and now known as IRS-2, was shown to become highly tyrosine phosphorylated in response to IL-4 or IGF-1 in cells lacking IRS-1. An additional member of this family of signaling intermediates, Shb, is a SH2-containing protein with characteristic proline-rich domains.For Research Use Only. Not Intended for Diagnostic or Therapeutic Use

Replacement monoclonal antibody for: sc-288, sc-1695.

衔接蛋白抗体、1.0ml磷酸缓冲盐溶液(含0.1%叠氮化钠和0.1%明胶)

MouseShc1

WB, IP, IF, IHC(P), FCM

6464;20416