SU5408

1/2

SU5408

品牌： Absin

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参数

分子式：

C₁₈H₁₈N₂O₃

分子量：

310.4

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产品介绍

产品信息

抗原名称

VEGFR2

商品描述

SU5408 is a highly selective, cell-permeable indolin-2-one class of receptor tyrosine kinase (RTK) inhibitor (IC50 = 70 nM) for murine vascular endothelial growth factor receptor 2 (VEGF-R2; KDR/Flk-1). The inhibition is suggested to be competitive with respect to ATP. VEGFR2 Kinase Inhibitor I has been shown to not inhibit PDGF, EGF, and IGF-1 RTK activities (IC50 > 100 μM).

分子量

310.4

纯度

98%

可溶性

DMSO : 6 mg/mL (19.33 mM; Need ultrasonic and warming)

In vitro(体外研究)

3-Substituted indolin-2-ones have been designed and synthesized as a novel class of tyrosine kinase inhibitors which exhibit selectivity toward different receptor tyrosine kinases (RTKs). These compounds have been evaluated for their relative inhibitory properties against a panel of RTKs in intact cells. SU5408 is found to be the most potent and selective VEGFR2 inhibitor among the compounds. SU5408 shows little or no effect against receptors for platelet-derived growth factor, epidermal growth factor, or insulin-like growth factor (IC50>100 µM).

背景

别名

VEGFR2 Kinase Inhibitor I

分子式

C₁₈H₁₈N₂O₃

CAS号

15966-93-5

制备和贮存

保存方式

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

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货号：

abs819500-5mg

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