T-5224

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T-5224

品牌： Absin

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参数

分子式：

C₂₉H₂₇NO₈

分子量：

517.53

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产品介绍

产品信息

抗原名称

MMP-3；MMP-13

商品描述

T-5224 is a selective inhibitor of c-Fos/activator protein (AP)-1, attenuates lipopolysaccharide-induced liver injury in mice.

分子量

517.53

纯度

>98%

可溶性

DMSO : ≥ 31 mg/mL (59.90 mM)

外观

Powder

In vitro(体外研究)

T-5224 (0-80 μM) significantly inhibits the invasion, migration, and MMP activity of HSC-3-M3 cells in a dose-dependent manner. There is no significant influence on HSC-3-M3 amd OSC-19 cells proliferation.

In vivo(体内研究)

G2 is observed in rat and monkey liver microsomes as a major metabolite of T-5224, suggesting that G2 is not a human-specific metabolite. T-5224 (300 mg/kg, p.o.) inhibits the production of TNF-alpha and other downstream effectors in C57BL/6 mice. Administration of T-5224 (300 mg/kg, p.o.) after intraperitoneal injection of LPS impartes appreciable protection against acute elevations in serum levels of TNFα, HMGB1, ALT/AST as well as in liver tissue levels of MIP-1α and MCP-1, and reduces the lethality (27%).

背景

别名

T-5224; T5224; T 5224.

分子式

C₂₉H₂₇NO₈

CAS号

530141-72-1

制备和贮存

保存方式

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

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货号：

abs810260-5mg

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