Tau (phospho T181) Mouse mAb (SDT-200-9)

Tau (phospho T181) Mouse mAb (SDT-200-9)

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    纯度:
    >95% by HPLC
    >95% by HPLC
    反应种属:
    Hu、Ms
    Hu、Ms
    展开
    产品介绍
    产品信息
    耦联标记
    Unconjugated
    纯化方式
    Protein G
    抗原名称
    Tau (phospho T181)
    宿主
    Mouse
    免疫原
    Synthetic Peptide
    同种型
    IgG1,k
    克隆号
    SDT-200-9
    纯度
    >95% by HPLC
    浓度
    5 mg/ml
    性状
    Liquid
    缓冲体系
    PBS pH7.4, 0.03% Proclin 300
    产品类型
    Mouse mAb
    应用
    实验应用
    Sandwich ELISA
    反应种属
    Hu、Ms
    预测反应种属
    Hu, Ms
    交叉反应性
    Does not recognize total Tau
    稀释度
    • Sandwich ELISA

      N/A
    背景
    别名
    p-Tau181, phospho T181
    背景

    Accumulation of intraneuronal neurofibrillary tangles (NFTs) containing paired helical filaments (PHFs) of the microtubule-associated protein tau is one of the defining neuropathological hallmarks of Alzheimer’s disease (AD). The tau protein has an N-terminal projection domain, a proline-rich region, a repeat region, and a C-terminal domain, with multiple potential phosphorylation sites along all regions. Studies using preparations of PHFs and immunohistochemical staining of postmortem brain tissue with specific tau antibodies established that PHF tau is hyperphosphorylated. High levels of p-tau and total tau (t-tau) have consistently been found in cerebrospinal fluid (CSF) of AD patients. However, while CSF t-tau is considered a non-specific biomarker of neuronal injury, p-tau may reflect AD-related tau pathology in the brain. The vast majority of CSF studies have used immunoassays detecting tau phosphorylated at threonine (Thr) 181 (p-tau181). During the last 2 decades, CSF p-tau181 together with total tau (t-tau) and amyloid-β 42 (Aβ42) have been extensively validated as biomarkers of AD and are currently widely used as diagnostic criteria in research studies, in clinical practice in some countries, and for patient selection in clinical trials. CSF p-tau181 (alone or in combination with Aβ42) accurately differentiates AD from controls and predicts cognitive decline in preclinical and prodromal disease stages. CSF p-tau181 levels are higher in AD compared with other tauopathies including frontotemporal dementia (FTD), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) and, hence, CSF p-tau181 has also been proven useful in differential diagnosis of dementia.

    制备和贮存
    保存方式

    12 months from date of receipt, 2 to 8 °C as supplied

    数据库链接
    Accession

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    货号:
    S0B3157-0.1mg
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