Product Details

The OX-26 monoclonal antibody reacts with rat CD71 also known as transferrin receptor protein 1 (TfR1). The antibody is reported to cross-react with mouse CD71 as well. CD71 is a 170-180 kDa type II homodimeric transmembrane glycoprotein which is expressed on the surface of proliferating cells, reticulocytes, and erythroid precursors. CD71 plays a role in the control of cellular proliferation and is required for iron import from transferrin into cells by endocytosis. CD71 is expressed on malignant cells at high levels and its expression correlates with cancer progression. This high expression on malignant cells along with CD71’s ability to internalize and the necessity of iron for cancer cell proliferation makes the transferrin receptor an attractive target to exploit for the delivery of drugs into malignant cells. Upon binding to an extracellular domain of CD71, OX-26 is transferred into the blood-brain barrier (BBB) via the endogenous transferrin transport system. Under this mechanism, the OX-26 antibody is often used to transport conjugated drugs across the BBB in experimental rat models.

Specifications

Isotype	Mouse IgG2a, κ
Recommended Isotype Control(s)	InVivoMAb mouse IgG2a isotype control, unknown specificity
Recommended Dilution Buffer	InVivoPure pH 7.0 Dilution Buffer
Conjugation	This product is unconjugated. Conjugation is available via our Antibody Conjugation Services.
Immunogen	PHA-activated PVG rat lymph node cells
Reported Applications	Targeted drug delivery to the brain Immunohistochemistry (frozen) Flow cytometry
Formulation	PBS, pH 7.0 Contains no stabilizers or preservatives
Endotoxin	<2EU/mg (<0.002EU/μg) Determined by LAL gel clotting assay
Purity	>95% Determined by SDS-PAGE
Sterility	0.2 μM filtered
Production	Purified from cell culture supernatant in an animal-free facility
Purification	Protein A
RRID	AB_2894751
Molecular Weight	150 kDa
Storage	The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.

组成成分

转铁蛋白受体蛋白1抗体，磷酸盐缓冲液

应用

反应种属

rat/mouse

背景

研究领域

Cancer Biology, Immunology, Tumor Antigens

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货号：

BE0331-1MG

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