Product Details

The 5E9C11 monoclonal antibody reacts with human CD71 also known as the transferrin receptor. CD71 is a type II homodimeric transmembrane glycoprotein which is expressed on the surface of proliferating cells, reticulocytes, and erythroid precursors. CD71 plays a role in the control of cellular proliferation and is required for iron import from transferrin into cells by endocytosis. CD71 is expressed on malignant cells at high levels and its expression correlates with cancer progression. This high expression on malignant cells along with CD71’s ability to internalize and the necessity of iron for cancer cell proliferation makes the transferrin receptor an attractive target to exploit for the delivery of drugs into malignant cells. The 5E9C11 antibody does not inhibit the binding of transferrin. This antibody has been previously used to deliver immunotoxins to human tumor xenografts in vivo in mice.

Specifications

Isotype	Mouse IgG1, κ
Recommended Isotype Control(s)	InVivoMAb mouse IgG1 isotype control, unknown specificity
Recommended Dilution Buffer	InVivoPure pH 7.0 Dilution Buffer
Conjugation	This product is unconjugated. Conjugation is available via our Antibody Conjugation Services.
Immunogen	Human acute lymphocytic leukemia T cell line HSB-2
Reported Applications	Western blot Immunoprecipitation Flow cytometry
Formulation	PBS, pH 7.0 Contains no stabilizers or preservatives
Endotoxin	<2EU/mg (<0.002EU/μg) Determined by LAL gel clotting assay
Purity	>95% Determined by SDS-PAGE
Sterility	0.2 μM filtered
Production	Purified from cell culture supernatant in an animal-free facility
Purification	Protein G
RRID	AB_2894762
Molecular Weight	150 kDa
Storage	The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.

组成成分

抗人转铁蛋白受体1抗体

应用

反应种属

Human

背景

研究领域

Cancer Biology, Tumor Antigens

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货号：

BE0343-1MG

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