Product Details

The R17 217.1.3/TIB-219 monoclonal antibody reacts with mouse CD71 also known as transferrin receptor protein 1 (TfR1). CD71 is a 170-180 kDa type II homodimeric transmembrane glycoprotein which is expressed on the surface of proliferating cells, reticulocytes, and erythroid precursors. CD71 plays a role in the control of cellular proliferation and is required for iron import from transferrin into cells by endocytosis. Due to its important role in proliferation and cellular iron intake as well as the fact that many cancerous cells express high levels of CD71 it is being explored as a potential new target in cases of human leukemia & lymphoma. The R17 217.1.3/TIB-219 antibody has been shown to deplete CD71+ erythroid splenocytes.

Specifications

Isotype	Rat IgG2a, κ
Recommended Isotype Control(s)	InVivoPlus rat IgG2a isotype control, anti-trinitrophenol
Recommended Dilution Buffer	InVivoPure pH 7.0 Dilution Buffer
Conjugation	This product is unconjugated. Conjugation is available via our Antibody Conjugation Services.
Immunogen	Mouse erythroleukemia cell line 745.6
Reported Applications	in vivo depletion of CD71+ cells
Formulation	PBS, pH 7.0 Contains no stabilizers or preservatives
Endotoxin*	<1EU/mg (<0.001EU/μg) Determined by LAL gel clotting assay
Aggregation*	<5% Determined by SEC
Purity	>95% Determined by SDS-PAGE
Sterility	0.2 μM filtered
Production	Purified from cell culture supernatant in an animal-free facility
Purification	Protein G
RRID	AB_10950526
Molecular Weight	150 kDa
Murine Pathogen Tests*	Ectromelia/Mousepox Virus: Negative Hantavirus: Negative K Virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Lymphocytic Choriomeningitis virus: Negative Mouse Adenovirus: Negative Mouse Cytomegalovirus: Negative Mouse Hepatitis Virus: Negative Mouse Minute Virus: Negative Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Rotavirus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Polyoma Virus: Negative Reovirus Screen: Negative Sendai Virus: Negative Theiler’s Murine Encephalomyelitis: Negative
Storage	The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.

* Additional quality control measures for our InVivoPlus™ products include advanced binding validation, murine pathogen screening, protein aggregation screening, and ultra-low endotoxin levels. The superior quality of our InVivoPlus™ products will meet and exceed the strict demands and rigorous standards required for in vivo research. Learn more about the InVivoPlus™ difference here.

组成成分

IGG-免疫球蛋白G型抗体

应用

反应种属

mouse

背景

研究领域

Cancer Biology, Tumor Antigens

声明：本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。

货号：

BP0175-5MG

一键复制

询价

5mg

25mg

50mg

100mg

选择数量

当前规格1件起购

配送至

预计2-3周送达，快递: 免运费，若需干冰额外收费

询价大包装询价