TGF-β RI Kinase Inhibitor VII

TGF-β RI Kinase Inhibitor VII is a cell-permeable quinoline compound which has been reported to act as a potent ATP-competitive inhibitor of ALK5/TGF-β Receptor I kinase activity, while inhibiting c-Src only at higher concentrations. It has been additionally reported to block Smad2/3 transcription activity and TGF-β-induced Smad2 phosphorylation in human lung cancer epithelial cell line A549.