Tivozanib

1/2

Tivozanib

品牌： Absin

下载产品说明书

用小程序，查商品更便捷

对比

咨询

参数

分子式：

C₂₂H₁₉ClN₄O₅

分子量：

454.86

展开

产品介绍

产品信息

抗原名称

VEGFR2 ,VEGFR3 ,EphB2 ,VEGFR1 ,PDGFRα

商品描述

Tivozanib (AV-951)是一种有效的，选择性VEGFR抑制剂，作用于VEGFR1/2/3时，IC50分别为0.21 nM/0.16 nM/0.24 nM，也抑制PDGFR和c-Kit，作用于FGFR-1， Flt3， c-Met EGFR和IGF-1R活性较弱。AV-951 也抑制PDGFRß和c-Kit的磷酸化作用，IC50 分别为1.72nm 和1.63nM。AV-951阻断VEGF依赖的MAPK活性和内皮细胞增殖。AV-951是新型喹啉-尿素派生物。

分子量

454.86

纯度

98%

可溶性

DMSO ：16 mg/mL (35.2 mM)

In vitro(体外研究)

AV-951 is a novel quinoline-urea derivative. AV-951 blocks VEGF-dependent activation of mitogen-activated protein kinases and proliferation of endothelial cells.

In vivo(体内研究)

In vivo studies show that AV-951 also decreases the micro vessel density and suppresses VEGFR2 phosphorylation levels in tumor xenografts, especially at a concentration of 1mg/kg (p.o. administration). AV-951 shows almost complete inhibition of tumor xenografts growth (TGI>85%) in athymic rats. Another study in rat peritoneal disseminated tumor model shows that AV-951 could prolong the survival of the tumor-bearing rats with the MST of 53.5 days. AV-951 displays antitumor activity against many human tumor xenografts including lung, breast, colon, ovarian, pancreas and prostate cancer.

背景

别名

替沃扎尼；AV-951；KRN951

分子式

C₂₂H₁₉ClN₄O₅

CAS号

475108-18-0

制备和贮存

保存方式

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

参考图片

声明：本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。

货号：

abs813179-5mg

一键复制

询价

5mg

10mg

50mg

选择数量

当前规格1件起购

配送至

预计1-2周送达，快递: 免运费，若需干冰额外收费

询价大包装询价