TNF-α Protein, Rat

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TNF-α Protein, Rat

品牌： UA BIOSCIENCE

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参数

分子量：

17kDa (Reducing)

纯度：

＞95% by SDS-PAGE

产品介绍

产品信息

耦联标记

Unconjugated

氨基酸序列

Leu80-Leu235

分子量

17kDa (Reducing)

生物活性

＜10pg/mL

纯度

＞95% by SDS-PAGE

内毒素水平

<0.1EU/μg

性状

Lyophilized Powder

表达系统

E.coli

缓冲体系

20mM Tris, 300mM NaCl, pH8.0

标签

No Tag

种属

Rat

电泳JSON

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2μg (R: reducing condition, N: non-reducing condition).

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背景

别名

TNF-α, TNF-alpha, Tumor necrosis factor ligand superfamily member 2, TNF-a, Cachectin, DIF, TNFA, TNFSF2

背景

Tumor Necrosis Factor alpha (TNF-α), is an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis. TNF alpha exerts many of its effects by binding to either a 55 kDa cell membrane receptor termed. TNFα activates signals through two receptors, TNF-R1, which is expressed on most cell types, and TNF-R2, which is expressed mainly on immune cells. TNFα can have many functions including, to stimulate of phagocytosis in macrophages, to chemoattract neutrophils, to increase insulin resistance and to induce fever.

制备和贮存

溶解方法

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

保存方式

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.

文献

1.Hector J. et al. (2007) TNF-alpha alters visfatin and adiponectin levels in human fat. Horm Metab Res. 39(4): 250-255.

2.Berthold-Losleben M. et al. (2008) The TNF-alpha System: Functional Aspects in Depression, Narcolepsy and Psychopharmacology. Curr Neuropharmacol. 6(3): 193-202.

数据库链接

Accession

P16599

参考图片

2μg (R: reducing condition, N: non-reducing condition).

Measured in a cell proliferation assay using L-929 mouse fibrosarcoma cells, the EC50 for this effect is less than 10pg/mL

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货号：

UA040217-1mg

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