TSLP Protein, Human

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TSLP Protein, Human

品牌： UA BIOSCIENCE

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参数

分子量：

13-15kDa (Reducing)

纯度：

>95% by SDS-PAGE

产品介绍

产品信息

耦联标记

Unconjugated

氨基酸序列

Tyr29-Gln159

分子量

13-15kDa (Reducing)

纯度

>95% by SDS-PAGE

内毒素水平

<0.1EU/μg

性状

Lyophilized Powder

表达系统

E.coli

缓冲体系

20mM Tris, 500mM NaCl, pH8.0

标签

No Tag

种属

Human

电泳JSON

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背景

别名

TSLP; Thymic stromal lymphopoietin

背景

Thymic stromal lymphopoietin (TSLP) acts as a hemopoietic cytokine, proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. It is positively associated with AD deterioration. Mainly secreted by keratinocytes, TSLP interacts with multiple immune cells (including dendritic cells, T cells, and mast cells), following induction of Th2-oriented immune response during the pathogenesis of AD.

制备和贮存

溶解方法

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

保存方式

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

· 3 months, -20 to -80℃ under sterile conditions after reconstitution.

· 1 week, 2 to 8℃ under sterile conditions after reconstitution.

· Please avoid repeated freeze-thaw cycles.

文献

1. Luo J, Zhu Z, Zhai Y, Zeng J, Li L, Wang D, Deng F, Chang B, Zhou J, Sun L. The Role of TSLP in Atopic Dermatitis: From Pathogenetic Molecule to Therapeutical Target. Mediators Inflamm. 2023 Apr 15;2023:7697699. 2. 2.Lu H, Wu X, Peng Y, Sun R, Nie Y, Li J, Wang M, Luo Y, Peng L, Fei Y, Zhou J, Zhang W, Zeng X. TSLP promoting B cell proliferation and polarizing follicular helper T cell as a therapeutic target in IgG4-related disease. J Transl Med. 2022 Sep 8;20(1):414.

数据库链接

Accession

Q969D9

参考图片

2μg (R: reducing conditions, N: non-reducing conditions).

Measured by its binding ability in a functional ELISA. When TSLP, Human is immobilized 10µg/mL (100µl/well), TSLPR His Tag，Human(Cat.No: UA010490) binds with an EC50 of 1.5-2.0μg/ml.

Anti-His antibody Immobilized on CM5 Chip captured TSLPR His Tag, Human (Cat. No. UA010490), can bind TSLP, Human (Cat. No. UA040102) with an affinity constant of 0.70 nM as determined in SPR assay.

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货号：

UA040102-100μg

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