UQCRFS1/RISP Antibody

Ubiquinol-cytochrome c reductase iron-sulfur subunit (UQCRFS1), also known as Rieske iron-sulfur protein (RISP), is a component of Complex III in the mitochondrial electron transport chain. UQCRFS1/RISP and two other subunits, cytochrome b (MT-CYB) and cytochrome c1 (CYC1), are essential for the catalytic activity of Complex III (1). Studies show that UQCRFS1/RISP is required for fetal mouse hematopoietic stem cell differentiation and adult mouse hematopoietic stem cell quiescence (2). In addition, loss of UQCRFS1/RISP decreases the strength of T cell receptor (TCR) signaling, indicating that this protein is critical for optimal TCR signaling (3). 1.Maio, N. et al. (2017) Cell Metab 25, 945-953.e6. 2.Ansó, E. et al. (2017) Nat Cell Biol 19, 614-625. 3.Weng, X. et al. (2021) Proc Natl Acad Sci U S A 118, e2021385118. doi: 10.1073/pnas.2021385118.