USP2 (Ubiquitin-specific Processing Protease 2, UBP41, Ubiquitin Specific Peptidase 2, USP9)

Fusion protein of human USP2

Suitable for use in ELISA and Immunohistochemistry. Other applications not tested.

This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

IgG

Polyclonal

Purified by immunoaffinity chromatography.

Suitable for use in ELISA and Immunohistochemistry. Other applications not tested.

ELISA: 1:2000-1:5000 Immunohistochemistry: 1:50-1:200 Optimal dilutions to be determined by the researcher.

Rabbit

Hu Mo Rt

Recognizes human USP2. Species Crossreactivity: mouse and rat

O75604