XPA (B-7)

mouse

XPA抗体(B-7)是小鼠单克隆mouse IgM κ (kappa轻链)，规格为200 µg/ml 特异性抗原位于human物种的XPA的N-terminus的氨基酸15-39之间 推荐用于 mouse, rat 和 human 来源的XPA WB, IP, IF 和 ELISA检测 目前，我们还没有完成XPA 抗体 (B-7)的首选二抗检测试剂的鉴定。这项工作正在进行中。 Xeroderma pigmentosum (XP) is an autosomal recessive disorder characterized by a genetic predisposition to sunlight-induced skin cancer due to deficiencies in the DNA repair enzymes. The most frequent mutations are found in the XP genes of group A through G and group V, which encode nucleotide excision repair proteins. Nucleotide excision repair (NER) is the normal cellular response to DNA damage induced by UV irradiation and is disrupted in patients with XP. Xeroderma pigmentosum group A (XPA) is an essential NER factor that coordinates the collection of a preincision complex during the processing of DNA damage. XPA may also have a role in the repair of oxidized DNA bases. XPA is sensitive not only to the structure of the DNA double helix, but also to bulky groups incorporated into DNA. XPA forms a homodimer in the absence of DNA, but binds to DNA in both monomeric and dimeric forms. The dimerically bound XPA is much more efficient, so cells probably regulate XPA activity in a concentration-dependent manner. XPA deficient organisms cannot repair UV-induced DNA damage and thus acquire skin cancers by UV irradiation very easily.For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

IGM-免疫球蛋白M型抗体

HumanXPA

human

7507;22590