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Z-DEVD-FMK

品牌： Absin

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参数

分子式：

C₃₀H₄₁FN₄O₁₂

分子量：

668.66

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产品介绍

产品信息

抗原名称

Caspase-3

商品描述

Z-DEVD-FMK是一种特异性，不可逆的Caspase-3抑制剂，也能有效抑制caspase-6， caspase-7， caspase-8和caspase-10。

分子量

668.66

纯度

98%

可溶性

DMSO : 100 mg/mL (149.55 mM)

外观

White to slightly brown solid

In vitro(体外研究)

Z-DEVD-FMK (1–200 μM) inhibits D4-GDI cleavage and apoptosis in a concentration-dependent manner. Z-DEVD-FMK reduces ceramide-induced cardiomyocyte death and significantly inhibits the activation of caspase 3. Z-DEVD-FMK (100μM) attenuates OxyHb-induced cell detachment, reduced caspase-2 and -3 activities, abolishes OxyHb-induced DNA ladders, and prevents OxyHb-induced cleavage of PARP in cultured brain microvessel endothelial cells. Z-DEVD-FMK (100 μM) blocks MPP+-induced increases in caspase-3 enzyme activity. Z-DEVD-FMK dose dependently blocks 6-OHDA-induced apoptotic cell death with IC50 of 18 μM.

In vivo(体内研究)

Z-DEVD-FMK, before and after injury, markedly reduces post-traumatic apoptosis, and significantly improved neurological recovery.

背景

别名

Caspase-3 Inhibitor

分子式

C₃₀H₄₁FN₄O₁₂

CAS号

210344-95-9

制备和贮存

保存方式

store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

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货号：

abs812077-1mg

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